131372-76-4

Upstream product

• 125399-34-0 -<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester 

Downstream Products

• 125399-59-9 ((1S,2S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionylamino}-3-cyclohexyl-1-hydroxy-propyl)-phosphonic acid dimethyl ester 
• 169529-79-7 (1S,2S)-N-<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>-N²-<(1,1-dimethylethoxy)carbonyl>-L-leucinamide 
• 125399-60-2 ((1S,2S)-3-Cyclohexyl-2-{(S)-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-2-isopropoxycarbonylamino-propionylamino}-1-hydroxy-propyl)-phosphonic acid dimethyl ester 
• 131372-78-6 {(1S,2S)-3-Cyclohexyl-1-hydroxy-2-[(S)-3-(3H-imidazol-4-yl)-2-isopropoxycarbonylamino-propionylamino]-propyl}-phosphonic acid dimethyl ester 
• 169529-81-1 (1S,2S)-N-<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>-N²--L-leucinamide 
• 131372-77-5 {(1S,2S)-2-[(S)-3-(3-Benzyloxymethyl-3H-imidazol-4-yl)-2-tert-butoxycarbonylamino-propionylamino]-3-cyclohexyl-1-hydroxy-propyl}-phosphonic acid dimethyl ester 
• 131434-98-5 (1S,2S)-N-<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>-N²--L-phenylalanyl>-L-leucinamide 

Relevant academic research and scientific papers

α-Hydroxy Phosphinyl-Based Inhibitors of Human Renin

The design and application of α-hydroxy phosphonates, a new class of transition state analogs, toward the discovery of novel and potent inhibitors of the aspartyl protease renin is described.Tripeptidic α-hydroxy diethyl phosphonate 3, the first example i

Preparation of peptidic α-hydroxy phosphonates. A new class of transition state analog renin inhibitors

A stereoselective synthesis of α-hydroxy phosphonates, a new class of transition state analog inhibitors is described. Methods of incorporating neutral and basic amino acid residues at the N-terminus of α-hydroxy-β-amino dimethyl phosphonate 8 are discuss