1254036-71-9 Usage
General Description
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole is a complex and long chemical compound that belongs to the class of indazole derivatives. It contains an indole ring, an oxazole ring, and a piperazine group, making it a heterocyclic compound. The chemical structure indicates potential pharmacological activity, as it contains a combination of aromatic and heterocyclic rings. 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole may have the potential to interact with biological systems, making it a potential candidate for further studies in medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 1254036-71-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,4,0,3 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1254036-71:
(9*1)+(8*2)+(7*5)+(6*4)+(5*0)+(4*3)+(3*6)+(2*7)+(1*1)=129
129 % 10 = 9
So 1254036-71-9 is a valid CAS Registry Number.
1254036-71-9Relevant articles and documents
Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib
Bream, Robert N.,Clark, Hugh,Edney, Dean,Harsanyi, Antal,Hayler, John,Ironmonger, Alan,Mc Cleary, Nadine,Phillips, Natalie,Priestley, Catherine,Roberts, Alastair,Rushworth, Philip,Szeto, Peter,Webb, Michael R.,Wheelhouse, Katherine
, p. 529 - 540 (2021/03/01)
This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in a pilot plant on a multikilogram scale to deliver >100 kg of product.
