125409-39-4

Upstream product

• 16290-20-3 1,4-bis(2,4-dimethoxyphenyl)butane-1,4-dione 
• 2746-25-0 p-Methoxybenzyl bromide 
• 93903-83-4 1-(2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)propan-1-one 
• 125304-89-4 2',4,4'-trimethoxydihydrochalcone trimethylsilyl enol ether 

Relevant academic research and scientific papers

Synthesis of 1,4-bis-(2,4-dimethoxyphenyl)-2,3-bis-(4-methoxybenzyl)butane-1,4-dione

The synthesis of meso and racemic 1,4-bis-(2,4-dimethoxyphenyl)-2,3-bis-(4-methoxybenzyl)-butane-1,4-dione, a brackenin like molecule from commercially available 2,4-dimethoxybenzaldehyde is described.

Medicinal Plants of Southern Africa. Part 4. Synthesis of Brackenin-like Molecules from 1,4-Dicarbonyl Precursors and by Oxydative Coupling. X-Ray Molecular Structure of Racemic-2,3-Dibenzyl-1,4-diphenylbutane-1,4-dione

Oxidative coupling of appropriate trimethylsilyl enol ethers is shown to give 1,4-diaryl-1,4-diketones in acceptable yields.Subsequent dibenzylation of these intermediates affords compounds related to the naturally occuring brackenin (1).Examination of these products by 1H n.m.r. and 13C n.m.r. demonstrates that these techniques can be used for the determination of relative configurations without resorting to X-ray crystallography.