93903-83-4

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 829-20-9 2',4'-dimethoxyacetophenone 
• 18493-30-6 1-(2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 
• 30925-62-3 metochalcone 

Downstream Products

• 125409-39-4 meso-(2R,3S)-1,4-bis(2,4-dimethoxyphenyl)-2,3-bis(4-methoxybenzyl)butane-1,4-dione 
• 89945-90-4 (2RS,3RS)-1,4-Bis-(2,4-dimethoxyphenyl)-2,3-bis-(4-methoxybenzyl)butane-1,4-dione 
• 125304-89-4 2',4,4'-trimethoxydihydrochalcone trimethylsilyl enol ether 

Relevant academic research and scientific papers

Monodisperse NiPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride as a catalyst for the highly efficient chemoselective reduction of α,β-unsaturated ketone compounds

Herein, the study reported extraordinary chemoselective reduction with selectivity (>99%) by the catalytic transfer hydrogenation of various α,β-unsaturated ketones with a catalyst of NiPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride (NiPd/mpg-C3N4) under mild conditions in a water/methanol medium. NiPd alloy NPs were synthesized by the reduction of metal salts in oleylamine (OAm) solution with the help of borane-tert-butylamine and then decorated on mpg-C3N4via a liquid phase self-assembly method. The NiPd/mpg-C3N4 nanocatalyst was characterized by TEM, XRD and ICP-MS. The NiPd/mpg-C3N4 nanocatalyst is a highly active catalyst for the chemoselective reduction of α,β-unsaturated ketones and all organic compounds were converted with high yield and 99% selectivity. In addition, the catalyst can be reused five times without an important loss in reaction yield. This journal is

Synthesis and activity of a new series of chalcones as aldose reductase inhibitors

A new series of chalcone derivatives has been synthesized and tested in vitro in order to assess their ability to inhibit aldose reductase enzyme (ALR2) and their specificity towards the target enzyme with respect to other oxidoreductases, such as aldehyde reductase, sorbitol dehydrogenase, and glutathione reductase. All the compounds display affinity for ALR2. The X-ray crystal structure of 1-(2,4-dihydroxyphenyl)-3-(2-methoxyphenyl)propen-1-one was determined.

A simple and efficient conversion of chalcones to dihydrochalcones

The remarcable efficiency of catalytic transfer hydrogenation of chalcones to dihydrochalcones using cyclohexene-Pd/C and ammonium formate-Pd/C is demonstrated.The method is preparatively simple and useful.