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1254178-08-9

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1254178-08-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1254178-08-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,4,1,7 and 8 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1254178-08:
(9*1)+(8*2)+(7*5)+(6*4)+(5*1)+(4*7)+(3*8)+(2*0)+(1*8)=149
149 % 10 = 9
So 1254178-08-9 is a valid CAS Registry Number.

1254178-08-9Downstream Products

1254178-08-9Relevant articles and documents

Novel amides and esters prodrugs of olmesartan: Synthesis, bioconversion, and pharmacokinetic evaluation

Park, Jin-Hun,Chang, Jeong-Soo,El-Gamal, Mohammed I.,Choi, Won-Kyoung,Lee, Woong San,Chung, Hye Jin,Kim, Hyun-Il,Cho, Young-Jin,Lee, Bong Sang,Jeon, Hong-Ryeol,Lee, Yong Sup,Choi, Young Wook,Lee, Jaehwi,Oh, Chang-Hyun

, p. 5895 - 5899 (2010)

Synthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters of IIa were studied and compared with those of olmesartan medoxomil. Compound IIa is proposed to be a promising prodrug of olmesartan.

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