761404-85-7Relevant articles and documents
A high purity of the preparation process of trityl olmesartan medoxomil
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Paragraph 0020; 0039-0044, (2019/03/21)
The invention discloses a preparation method of a triphenyl methyl olmesartan intermediate compound I. The method comprises the steps of a) hydrolyzing a compound II in the presence of alkali to generate a compound III; b) performing a condensation reaction on the compound III and a compound IV in the presence of a catalyst to prepare a compound I; c) adding water in the step b), and then extracting by using a halogenated hydrocarbon solvent system; d) concentrating the compound I obtained in the step c). The equation is as shown in the specification. The preparation method disclosed by the invention is mild in reaction conditions, small in by-products, high in purity of final products and high in yield; the preparation process is environment-friendly, and is low in wastewater production and beneficial in industrial mass production.
Method of Producing Related Substance of Olmesartan Medoxomil
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Paragraph 0018-0021, (2017/07/26)
PURPOSE: A method for preparing a related substance of olmesartan medoxomil is provided to control particle size and to enable easy preparation. CONSTITUTION: A method for preparing a related substance of olmesartan medoxomil comprises: a step of reacting ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazole-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate with lithium hydroxide to prepare 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazole-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate in a mixture solvent of water and dioxane; and a step of reacting the prepared compound with ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazole-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate under the presence of tetrahydro furane and benzene sulfonic acid.
Preparation method of key intermediate of olmesartan medoxomil and olmesartan medoxomil
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Paragraph 0058; 0059; 0060; 0061; 0062; 0063, (2016/10/17)
The invention relates to a preparation and refinement method of a key intermediate of olmesartan medoxomil and the olmesartan medoxomil, and belongs to the technical field of medicine. The structural formula of the olmesartan medoxomil is shown as a formula I (Please see the specification).