125419-80-9

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3,5-Dibromo-4-ethylpyridine is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, playing a crucial role in the development of new drugs and pesticides.
Used in Antimicrobial and Antifungal Agents:
Leveraging its biocidal properties, 3,5-Dibromo-4-ethylpyridine is employed in the development of antimicrobial and antifungal agents, contributing to the creation of products that combat microbial infections and fungal growth.
Used in Organic Synthesis:
As a valuable reagent in organic synthesis, 3,5-Dibromo-4-ethylpyridine aids in the production of a variety of chemical compounds, facilitating advancements in the field of chemistry.
Used in Specialty Chemicals Production:
3,5-Dibromo-4-ethylpyridine is also used in the manufacturing process of specialty chemicals, underscoring its importance in the chemical industry for producing unique and specialized products.

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 74-88-4 methyl iodide 
• 75-03-6 ethyl iodide 
• 536-75-4 4-Ethylpyridine 

Downstream Products

• 1373522-31-6 4-(5-(5-(3-cyano-4-isobutylphenyl)-1,2,4-thiadiazol-3-yl)-4-ethylpyridin-3-yl)butanoic acid 
• 1373522-30-5 4-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-4-ethylpyridin-3-yl)butanoic acid 
• 1373522-81-6 5-(3-(5-bromo-4-ethylpyridin-3-yl)-1,2,4-thiadiazol-5-yl)-2-isobutylbenzonitrile 
• 1373522-80-5 3-(5-bromo-4-ethylpyridin-3-yl)-5-(3-chloro-4-isopropoxyphenyl)-1,2,4-thiadiazole 
• 1373522-79-2 3-(5-bromo-4-ethylpyridin-3-yl)-5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazole 
• 1373522-78-1 (5-bromo-4-ethylpyridin-3-yl)boronic acid 

Relevant academic research and scientific papers

Synthesis of 4-alkyl-3,5-dibromo-, 3-bromo-4,5-dialkyl- and 3,4,5-trialkylpyridines via sequential metalation and metal-halogen exchange of 3,5-dibromopyridine

Lithiation of 3,5-dibromopyridine with LDA and subsequent reaction with electrophiles provided 4-alkyl-3,5-dibromopyridines 2 in high yield. 3-Bromo-4,5-dialkylpyridines 3 were synthesized by metal-halogen exchange of 2 with one equivalent n-BuLi and reaction with a second electrophile. Further metal-halogen exchange of 3 and reaction with a third electrophile provided 3,4,5-trisubstituted pyridines 4.

ISOQUINOLINES AS INHIBITORS OF HPK1

Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P1)

A novel series of 1,2,4-thiadiazole compounds was discovered as selective S1P1 agonists. The extensive structure-activity relationship studies for these analogues were reported. Among them, 17g was identified to show high in vitro potency with reasonable free unbound fraction in plasma (Fu > 0.5%), good brain penetration (BBR > 0.5), and desirable pharmacokinetic properties in mouse and rat. Oral administration of 1 mg/kg 17g resulted in significant peripheral lymphocytes reduction at 4 h after dose and rapid lymphocytes recovery at 24 h. 17g showed a transient lymphopenia profile in the repeated dose study in mouse. In addition, 17g also demonstrated efficacy comparable to that of FTY720 (1) in the mouse EAE model of MS.