1254190-55-0Relevant articles and documents
SO 3H -functionalized magnetic Fe 3O 4 nanoparticles as an efficient and reusable catalyst for one-pot synthesis of α -amino phosphonates
Hamadi, Hosein,Norouzi, Meysam
, (2018)
Abstract: Nanomagnetic Fe 3O 4@ SiO 2-SO 3H (SO 3H-MNPs) was prepared via grafting sulfonic acid on the silica-coated Fe 3O 4 magnetite nanoparticles (MNPs). The catalytic activi
Radical Cation Salt-initiated Aerobic C?H Phosphorylation of N-Benzylanilines: Synthesis of α-Aminophosphonates
Jia, Xiaodong,Liu, Xiaofei,Yuan, Yu,Li, Pengfei,Hou, Wentao,He, Kaixuan
supporting information, p. 1911 - 1914 (2018/07/31)
A radical cation salt-initiated phosphorylation of N-benzylanilines was realized through an aerobic oxidation of the sp3 C?H bond, providing a series of α-aminophosphonates in high yields. An investigation of the reaction scope revealed that this mild catalyst system is superior in good functional group tolerance and high reaction efficiency. The mechanistic study implied that the cleavage of the sp3 C?H bond was involved in the rate-determining step.
Highly efficient synthesis of α-aminophosphonates catalyzed by hafnium(IV) chloride
Li, Xiao-Chuan,Gong, Shan-Shan,Zeng, De-Yun,You, Yue-Hai,Sun, Qi
, p. 1782 - 1785 (2016/04/05)
A highly efficient one-pot method for the synthesis of a variety of α-aminophosphonates via the one-pot three-component reaction of aldehyde, amine, and phosphite has been developed using only 2 mol % HfCl4 as the catalyst. The NMR evidence strongly indicated the catalytic roles of Hf(IV) on the activation of aldehyde, phosphite, and imine intermediate.
A Green Approach to the Synthesis of α-Amino Phosphonate in Water Medium: Carbene Insertion into the N-H Bond by Cu(I) Catalyst
Ramakrishna, Kankanala,Thomas, Jisha Mary,Sivasankar, Chinnappan
, p. 9826 - 9835 (2016/11/02)
Synthesis of amino phosphonates is more important owing to their significant applications in the biological systems. There are few methods already known in the literature to make these molecules; however, known methods have their own disadvantages. In this regard, synthesis of different kinds of amino phosphonates have been achieved via phosphonate substituted carbene insertion into the N-H bond of aniline catalyzed by readily available copper salt under mild reaction conditions in water. In order to find an efficient catalyst for carbene insertion reaction in neat water, a large number of transition metal catalysts were screened, and we found that the [Cu(CH3CN)4]ClO4 was the best catalyst under employed reaction conditions. Using this environmentally benign methodology (copper catalyzed reaction in water), a large number of biologically important amino phosphonates have been synthesized, isolated (37 examples), and characterized using standard analytical and spectroscopic techniques.
Ultrasound mediated synthesis of α-aminophosphonates and 3,4-dihydropyrimidin-2-ones using graphene oxide as a recyclable catalyst under solvent-free conditions
Bhattacharya, Tamalika,Majumdar, Biju,Dey, Deepa,Sarma, Tridib K.
, p. 45831 - 45837 (2015/02/19)
Graphene oxide is utilized as an environmentally friendly and efficient catalyst for an ultrasound mediated multi-component coupling reaction that involves aldehyde, amine/ethylacetoacetate and diethyl phosphite/urea, under solvent-free conditions, leading to the bioactive α-aminophosphonates and 3,4-dihydropyrimidin-2-ones with excellent yield. This journal is
CeCl37H2O-catalyzed one-pot Kabachnik-Fields reaction: A green protocol for three-component synthesis of α- aminophosphonates
Jafari, Abbas Ali,Nazarpour, Mahshid,Abdollahi-Alibeik, Mohammad
experimental part, p. 397 - 403 (2011/07/07)
CeCl37H2O has been utilized as an efficient Lewis acid catalyst for the three-component coupling of aldehydes, aromatic amines, and diethylphosphite to produce α-aminophosphonates under solvent-free conditions. The advantages of this protocol are high yield, mild reaction conditions, less environmental pollution, and simple work-up procedure.
