1254339-46-2Relevant academic research and scientific papers
Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase
Antczak, Christophe,Shum, David,Bassit, Bhramdeo,Frattini, Mark G.,Li, Yueming,Stanchina, Elisa De,Scheinberg, David A.,Djaballah, Hakim
, p. 4528 - 4532 (2011/09/12)
Selective inhibitors of human peptide deformylase (HsPDF) are predicted to constitute a new class of antitumor agents. We report the identification of benzofuran-4,5-diones as the first known selective HsPDF inhibitors and we describe their selectivity pr
BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS
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Page/Page column 117; 130; 131, (2010/11/18)
The instant invention provides novel benzofuran-4,5-diones and pharmaceutical compositions thereof useful for inhibiting PDF and for treating proliferative and infectious diseases. Compounds may be selective for eukaryotic (e.g., human) PDF or prokaryotic PDF
