1254367-89-9

Upstream product

• 1254367-68-4 phenyl 2-amino-5-(benzyloxy)-6-bromo-3-methylisonicotinate 
• 1254367-70-8 phenyl 3-(benzyloxy)-2-bromo-6-fluoro-5-methylisonicotinate 
• 1254367-86-6 phenyl 5-benzyloxy-6-[(t-butoxycarbonyl)amino]-2-fluoro-3-methylisonicotinate 
• 1254367-87-7 phenyl 3-benzyloxy-2-[bis(t-butoxycarbonyl)amino]-6-fluoro-5-methylisonicotinate 
• 100-51-6 benzyl alcohol 
• 1254367-43-5 C₂₀H₁₇NO₄ 
• 1254367-38-8 phenyl 5-(benzyloxy)-2-bromo-3-methylisonicotinate 
• 1253799-65-3 phenyl 3-(benzyloxy)-5-methylisonicotinate 
• 1253799-63-1 phenyl 3-(benzyloxy)-5-chloroisonicotinate 
• 1253799-61-9 3-(benzyloxy)-5-chloroisonicotinic acid 
• 1254367-40-2 phenyl 3-(benzyloxy)-2,6-dibromo-5-methylisonicotinate 
• 1254367-44-6 C₂₀H₁₆BrNO₄ 
• 1254367-88-8 2-[(4aS,11aR,12aS,13S)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[5',4':6,7]naphth[2,3-g]isoquinolin-8-yl]-imidodicarbonic acid, 1,3-bis(1,1-dimethylethyl) ester 

Downstream Products

• 1254367-90-2 C₄₆H₅₆FN₅O₈Si 

Relevant academic research and scientific papers

8-azatetracyclines: Synthesis and evaluation of a novel class of tetracycline antibacterial agents

A novel series of fully synthetic 8-azatetracyclines was prepared and evaluated for antibacterial activity. Compounds were identified that overcome both efflux (tet(K)) and ribosomal protection (tet(M)) tetracycline resistance mechanisms and are active against Gram-positive and Gram-negative organisms. Two compounds were identified that exhibit comparable efficacy to marketed tetracyclines in in vivo models of bacterial infection.

8-AZA TETRACYCLINE COMPOUNDS

The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use.