125441-95-4

Upstream product

• 125414-87-1 6-(p-methylphenoxy)-3-methyl<1,3>oxazino<4,5-c>isoquinolin-1-one 
• 125414-84-8 3-amino-1-(p-methylphenoxy)isoquinoline-4-carboxylic acid 
• 125414-82-6 ethyl 3-amino-1-bromoisoquinoline-4-carboxylate 
• 86369-35-9 cyano acetic acid ethyl ester 
• 125414-83-7 ethyl 3-amino-1-(p-methylphenoxy)isoquinoline-4-carboxylate 
• 3759-28-2 (2-cyanophenyl)acetonitrile 
• 106-44-5 p-cresol 
• 125414-88-2 3-[(N-Butyl-acetimidoyl)-amino]-1-p-tolyloxy-isoquinoline-4-carboxylic acid 

Relevant academic research and scientific papers

Ethoxycarbonylation of α-Cyano-o-toluonitrile and Cyclization to Isoquinolines and Pyrimidoisoquinolines

α-cyano-o-toluonitrile is α-ethoxycarbonylated with ethyl chloroformate and 4-dimethylaminopyridine, and cyclized to ethyl 3-amino-1-bromoisoquinoline-4-carboxylate.This is further functionalized, and examples of third-ring annulation to pyrimidoisoquinolines are reported.