86369-35-9

Upstream product

• 3759-28-2 (2-cyanophenyl)acetonitrile 
• 541-41-3 chloroformic acid ethyl ester 
• 394-47-8 2-fluorobenzonitrile 
• 105-56-6 ethyl 2-cyanoacetate 
• 2042-37-7 o-cyanobromobenzene 

Downstream Products

• 125414-83-7 ethyl 3-amino-1-(p-methylphenoxy)isoquinoline-4-carboxylate 
• 125414-84-8 3-amino-1-(p-methylphenoxy)isoquinoline-4-carboxylic acid 
• 125414-87-1 6-(p-methylphenoxy)-3-methyl<1,3>oxazino<4,5-c>isoquinolin-1-one 
• 125441-95-4 2-butyl-6-(p-methylphenoxy)-3-methylpyrimido<4,5-c>isoquinolin-1(2H)-one 
• 125414-88-2 3-[(N-Butyl-acetimidoyl)-amino]-1-p-tolyloxy-isoquinoline-4-carboxylic acid 
• 3759-28-2 (2-cyanophenyl)acetonitrile 

Relevant academic research and scientific papers

Efficient methods for the synthesis of arylacetonitriles

Various approaches to [2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile were investigated. Two of these methods were selected and applied to a variety of electron-deficient substrates, thereby expanding the scopes of the procedures.

Ethoxycarbonylation of α-Cyano-o-toluonitrile and Cyclization to Isoquinolines and Pyrimidoisoquinolines

α-cyano-o-toluonitrile is α-ethoxycarbonylated with ethyl chloroformate and 4-dimethylaminopyridine, and cyclized to ethyl 3-amino-1-bromoisoquinoline-4-carboxylate.This is further functionalized, and examples of third-ring annulation to pyrimidoisoquinolines are reported.

STUDIES ON SRN1 REACTIONS. PART 8 NEW AND DIRECT ARYLATION AND HETARYLATION OF β-DICARBONYL COMPOUNDS BY SRN1

Arylation of β-dicarbonyl compounds is carried out by photostimulated SRN1 reaction between bromobenzonitriles or bromocyanopyridine and β-dicarbonyl derived monoanions.