125470-94-2Relevant academic research and scientific papers
Cobalt-Catalyzed C(sp2)-H Carbonylation of Amino Acids Using Picolinamide as a Traceless Directing Group
Lukasevics, Lukass,Cizikovs, Aleksandrs,Grigorjeva, Liene
, p. 2748 - 2753 (2021)
Herein we report an efficient protocol for the C(sp2)-H carbonylation of amino acid derivatives based on an inexpensive cobalt(II) salt catalyst. Carbonylation was accomplished using picolinamide as a traceless directing group, CO (1 atm) as the carbonyl
A convenient and efficient synthesis of dipeptidyl benzoxaboroles and their peptidomimetics
Fu, Zhengyan,He, Jiangpeng,Tong, Aiping,Xie, Yongmei,Wei, Yuquan
supporting information, p. 2843 - 2852 (2013/10/22)
We have developed a convenient and efficient method for the synthesis of dipeptidyl benzoxaboroles and their peptidomimetics. The novel dipeptidyl benzoxaboroles were obtained by the protecting-group-free coupling of 6-amino-1,3-dihydro-2,1-benzoxaborol-1-ol with various N-(arylcarbonyl) phenylalanines. Bioisosteric replacement of the terminal amide moiety of dipeptidyl benzoxaboroles by 1,3,4-oxadiazoles or 4H-3,1-benzothiazin-4-one provided their peptidomimetics with good molecular diversity. These transformations were based on the pluripotency of methyl (S)-2-isothiocyanato-3- phenylpropanoate and were highlighted by mild reaction conditions, high atom efficiency, and good to excellent isolated yields. This method is a valuable addition to the development of novel drug-like boronic acid molecules. Georg Thieme Verlag Stuttgart ? New York.
N4-tetradentate dicarboxyamidate/dipyridyl palladium complexes as robust catalysts for the Heck reaction of deactivated aryl chlorides
Srinivas, Pottabathula,Likhar, Pravin R.,Maheswaran, Hariharasarma,Sridhar, Balasubramanian,Ravikumar, Krishnan,Kantam, Mannepalli Lakshmi
supporting information; experimental part, p. 1578 - 1581 (2009/09/05)
The utility of palladium(II) complexes of tetradentate dicarboxyamide/ dipyridyl ligands as catalysts for the Heck reaction of deactivated aryl chlorides and olefins was studied. The square-planar palladium complexes were prepared by treatment of the ligands with Pd(OAc)2 in THF at room temperature. Thermogravimetric analysis show that both the palladium complexes have high thermal stability up to 350°C. LiOH·H2O has a pronounced effect on the product yield, while a yield of 74% is obtained by using DMA as a solvent at 160°C in 44 h. The reactions of less reactive aryl chlorides such as 4-chloroanisole, 4-chlorotoluene, and chlorobenzene with styrene and 4-methylstyrene, proceed smoothly and provide good yields. Both palladium complexes are found to be efficient and active for the Heck reaction of deactivated aryl chlorides and olefins.
