1254703-76-8

Basic information

• Product Name: C₁₆H₁₄N₄O₃
• CAS NO: 1254703-76-8
• Molecular Weight: 310.312
• Mol File: 1254703-76-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₄N₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₄N₄O₃(1254703-76-8)
• EPA Substance Registry System: C₁₆H₁₄N₄O₃(1254703-76-8)

Safety Data

• Hazardous Substances Data: 1254703-76-8(Hazardous Substances Data)

Upstream product

• 1254703-62-2 C₁₆H₁₃ClN₄O₂ 
• 114150-57-1 4,6-dioxo-6-phenyl-hexanoic acid 
• 98-86-2 acetophenone 

Relevant articles and documents

Synthesis of 1,5-diarylpyrazol-3-propanoic acids towards inhibition of cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4 formation

A set of 25 derivatives of 3-[1-(6-substituted-pyridazin-3-yl)-5-(4- substitutedphenyl)-1H-pyrazol-3-yl]propanoic acids has been synthesized and evaluated for their in vitro cyclooxygenase-1/2 (COX-1/ 2) inhibitory activity using assays with purified COX-1 and COX-2 enzymes as well as for their 5-lipoxygenase (5-LO)-mediated LTB4 formation inhibitory activity using an assay with activated human polymorphonuclear leukocytes (PMNL). Among the synthesized compounds, especially 4g showed COX-1 (IC50 = 1.5 μM) and COX-2 (IC50 = 1.6 μM) inhibitory activity, whereas compounds 4b and 4 f resulted in the inhibition of 5-LO-mediated LTB4 formation at 14 μM and 12 μM IC50 values, respectively, without any significant inhibition on COX isoforms. ECV · Editio Cantor Verlag.