1254705-01-5Relevant academic research and scientific papers
Diaryldiamines with dual inhibition of the histamine H3 receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1- phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain
Altenbach, Robert J.,Black, Lawrence A.,Strakhova, Marina I.,Manelli, Arlene M.,Carr, Tracy L.,Marsh, Kennan C.,Wetter, Jill M.,Wensink, Erica J.,Hsieh, Gin C.,Honore, Prisca,Garrison, Tiffany Runyan,Brioni, Jorge D.,Cowart, Marlon D.
experimental part, p. 7869 - 7873 (2011/01/12)
A series of compounds was designed as dual inhibitors of the H3 receptor and the norepinephrine transporter. Compound 5 (rNET Ki = 14 nM; rH3R Ki = 37 nM) was found to be efficacious in a rat model of osteoarthritic pain.
