60709-31-1Relevant academic research and scientific papers
A model target anti-tumor medicament and its preparation method and application (by machine translation)
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Paragraph 0059-0061, (2016/10/10)
This invention relates to the targeting of antineoplastic eEF2K of a small molecule inhibitor, its formula (I), formula (II) the structure of the formula (III): Formula (I), formula (II) compound of the formula (III) structure and its pharmaceutically acceptable salt thereof can kill cancer cells, the healthy organism cells are not affected, to various tumor is markedly inhibited, in particular breast cancer, glioma, stomach cancer, liver cancer cells is markedly inhibited. (by machine translation)
Diaryldiamines with dual inhibition of the histamine H3 receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1- phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain
Altenbach, Robert J.,Black, Lawrence A.,Strakhova, Marina I.,Manelli, Arlene M.,Carr, Tracy L.,Marsh, Kennan C.,Wetter, Jill M.,Wensink, Erica J.,Hsieh, Gin C.,Honore, Prisca,Garrison, Tiffany Runyan,Brioni, Jorge D.,Cowart, Marlon D.
supporting information; experimental part, p. 7869 - 7873 (2011/01/12)
A series of compounds was designed as dual inhibitors of the H3 receptor and the norepinephrine transporter. Compound 5 (rNET Ki = 14 nM; rH3R Ki = 37 nM) was found to be efficacious in a rat model of osteoarthritic pain.
Substituted N-arylanilines
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, (2008/06/13)
N-Arylanilines, further substituted on nitrogen by aroyl, aralkanoyl or aralkyl groups, and wherein one of the aryl groups has a 3- or 4-(aminoalkoxy)substituent, having hypocholesteremic activity, are prepared by a series of O-alkylation, N-acylation or -alkylation, and reduction reactions starting from the appropriate hydroxydiarylamines or benzyl ethers thereof.
