1254708-06-9Relevant academic research and scientific papers
A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins
Leggans, Erick K.,Akey, David L.,Smith, Janet L.,Fecik, Robert A.
, p. 5939 - 5942 (2010)
A general strategy to enzymatically label acyl carrier proteins (ACPs) of polyketide synthases has been developed. Incorporation of a chloromethyl ketone or vinyl ketone moiety into polyketide chain elongation intermediate mimics allows for the synthesis of CoA adducts. These CoA adducts undergo enzymatic reaction with Sfp, a phosphopantetheinyl transferase, to afford labeled CurB carrier proteins.
