Bioorganic and Medicinal Chemistry Letters p. 5939 - 5942 (2010)
Update date:2022-08-04
Topics:
Leggans, Erick K.
Akey, David L.
Smith, Janet L.
Fecik, Robert A.
A general strategy to enzymatically label acyl carrier proteins (ACPs) of polyketide synthases has been developed. Incorporation of a chloromethyl ketone or vinyl ketone moiety into polyketide chain elongation intermediate mimics allows for the synthesis of CoA adducts. These CoA adducts undergo enzymatic reaction with Sfp, a phosphopantetheinyl transferase, to afford labeled CurB carrier proteins.
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Doi:10.1002/adsc.201000246
(2010)Doi:10.1016/S0040-4020(01)81315-6
(1989)Doi:10.1002/anie.201002485
(2010)Doi:10.1007/s13738-012-0093-4
(2012)Doi:10.1002/ejoc.201000721
(2010)Doi:10.1016/j.tetlet.2010.08.044
(2010)
