1254734-41-2Relevant academic research and scientific papers
Synthesis and evaluation of anticonvulsant activity of N -(2,5-dimethylphenoxy)-and N-[(2,3,5-trimethylphenoxy)alkyl] aminoalkanols
Waszkielewicz, Anna Maria,Gunia-Krzyzak, Agnieszka,Ceg? A, Marek,Marona, Henryk
, p. 89 - 99 (2015/02/05)
AseriesofnewN-(2,5-dimethylphenoxy)-andN-(2,3,5-trimethylphenoxy)alkylaminoalkanols [I-XVII]wassynthesizedandevaluatedforanticonvulsantactivity.Pharmacologicaltestsincludedmaximal electroshock(MES)andsubcutaneouspentetrazoleseizurethreshold(scMet)assaysaswellasneurotoxicity (TOX)evaluationinmiceafterintraperitoneal(i.p.)administrationand/orinratsafteroral(p.o.)administration. ThemostactivecompoundwasR-2N-[(2,3,5-trimethylphenoxy)ethyl]aminobutan-1-ol,whichexhibited 100%activityinMESatthedoseof30mg/kgbodyweight(mice,i.p.)and75%activityinMESat30mg/kg b.w.(rats,p.o.)withoutneurotoxicityattheactive doses.
