96-20-8Relevant articles and documents
CONTINUOUS FLOW PROCESS AND APPARATUS FOR MANUFACTURE OF DL-2-NITRO-1-BUTANOL
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Paragraph 0035-0040, (2021/02/12)
A continuous process(200) for manufacture of dl-2-nitro-1-butanol from 1-nitropropane is disclosed. The process mixes aqueous solution of sodium hydroxide (A) and a solution of 1-nitropropane (B) dissolved in alcohol(203) at a first molar ratio in a first tubular reactor to form a mixture. The mixture is pumped(205) with an aqueous solution of formaldehyde at a second predetermined molar ratio to a second tubular reactor for a second residence time to form a product stream. The product stream is quenched(207) in glacial acetic acid to obtain quench liquor having dl-2-nitro-1-butanol. The first(130) and the second(150) tubular reactors are maintained at a temperature of 35° C or less. The method produces conversion of at least 89% dl-2-nitro-1-butanol with residence time of 30 minutes or less. Apparatus for continuous production of dl-2-nitro-1-butanol from 1-nitropropane is further disclosed. A method of obtaining dl-2-amino-1-butanol by hydrogenation of the dl-2-nitro-1-butanol is further disclosed.
Borohydride reduction stabilizing system and method for reducing ester into alcohol
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Paragraph 0110; 0111; 0112, (2019/09/13)
The invention provides a borohydride reduction stabilizing system and a method for reducing ester into alcohol. The borohydride reduction stabilizing system comprises a borohydride reducing agent anda stabilizer for stabilizing the borohydride reducing agent, wherein the borohydride reducing agent is sodium borohydride or potassium borohydride, and the stabilizer is an alkali metal salt of alcohol. On the basis of an existing sodium borohydride/potassium reducing agent, an alcohol alkali metal salt (such as sodium alcoholate or potassium alcoholate) is added, and then the sodium borohydride/potassium reducing agent can keep stable and is not decomposed under a heating condition, so that on one hand, reduction activity is maintained in a relatively high state and the situation of excessiveuse is reduced, and on the other hand, generation of hydrogen is reduced and the process risk is reduced.
NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND USE
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Paragraph 0532, (2019/01/17)
Disclosed are a nitrogenous heterocyclic compound, intermediates, a preparation method, a composition and use thereof. The nitrogenous heterocyclic compound in the present invention is as shown in formula I. The compound has a high inhibitory activity towards ErbB2 tyrosine kinase and a relatively good inhibitory activity towards human breast cancer BT-474 and human gastric cancer cell NCI-N87 which express ErbB2 at a high level, and at the same time has a relatively weak inhibitory activity towards EGFR kinase. Namely, the compound is a highly selective small-molecule inhibitor targeted at ErbB2, and hence it has a high degree of safety, and can effectively enlarge the safety window in the process of taking the drug.
