1254765-80-4Relevant academic research and scientific papers
STIMULUS-TRIGGERED PRODRUGS
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Page/Page column 46, (2012/01/13)
Set forth herein, inter alia, are compositions and methods for treating diseases with prodrugs. Provided herein are prodrug compositions for inhibiting the function of proteins, compositions and methods for treating diseases associated with oxidative compounds, oxidatively-sensitive prodrugs of inhibitors of metalloproteases. and methods of inhibiting metalloproteases using oxidatively-sensitive prodrugs.
Hydrogen peroxide activated matrix metalloproteinase inhibitors: A prodrug approach
Major Jourden, Jody L.,Cohen, Seth M.
supporting information; experimental part, p. 6795 - 6797 (2010/12/19)
(Figure Presented) Doing double duty: A metalloproteinase inhibitor that can be activated by reactive oxygen species (ROS) has been designed to protect the blood-brain barrier (BBB) in ischemic reperfusion injury. By both neu-tralizing damaging ROS and inhibiting degradative metalloproteinases, a single compound can eliminate both threats to the BBB upon activation.
