1254841-08-1 Usage
Uses
Used in Pharmaceutical Industry:
Sitagliptin is utilized as an antidiabetic agent for the treatment of type 2 diabetes. It is effective in managing blood sugar levels by increasing insulin levels and decreasing glucose production in the liver. Its mechanism of action involves inhibiting DPP-4, thus maintaining the activity of incretin hormones that play a crucial role in glucose homeostasis.
Additionally, Sitagliptin is often used in combination with other antidiabetic medications to achieve a more comprehensive management of blood sugar levels in patients with type 2 diabetes. This combination therapy can lead to better glycemic control and may help prevent the progression of the disease.
Check Digit Verification of cas no
The CAS Registry Mumber 1254841-08-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,4,8,4 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1254841-08:
(9*1)+(8*2)+(7*5)+(6*4)+(5*8)+(4*4)+(3*1)+(2*0)+(1*8)=151
151 % 10 = 1
So 1254841-08-1 is a valid CAS Registry Number.
1254841-08-1Relevant academic research and scientific papers
Asymmetric synthesis of telcagepant, a CGRP receptor antagonist for the treatment of migraine
Xu, Feng,Zacuto, Michael,Yoshikawa, Naoki,Desmond, Richard,Hoerrner, Scott,Itoh, Tetsuji,Journet, Michel,Humphrey, Guy R.,Cowden, Cameron,Strotman, Neil,Devine, Paul
experimental part, p. 7829 - 7841 (2011/02/22)
A highly efficient, asymmetric synthesis of telcagepant (1), a CGRP receptor antagonist for the treatment of migraine, is described. This synthesis features the first application of iminium organocatalysis on an industrial scale. The key to the success of
