1254841-09-2Relevant academic research and scientific papers
Asymmetric synthesis of telcagepant, a CGRP receptor antagonist for the treatment of migraine
Xu, Feng,Zacuto, Michael,Yoshikawa, Naoki,Desmond, Richard,Hoerrner, Scott,Itoh, Tetsuji,Journet, Michel,Humphrey, Guy R.,Cowden, Cameron,Strotman, Neil,Devine, Paul
scheme or table, p. 7829 - 7841 (2011/02/22)
A highly efficient, asymmetric synthesis of telcagepant (1), a CGRP receptor antagonist for the treatment of migraine, is described. This synthesis features the first application of iminium organocatalysis on an industrial scale. The key to the success of
Asymmetric hydrogenation of protected allylic amines
Steinhuebel, Dietrich P.,Krska, Shane W.,Alorati, Anthony,Baxter, Jenny M.,Belyk, Kevin,Bishop, Brian,Palucki, Michael,Sun, Yongkui,Davies, Ian W.
supporting information; experimental part, p. 4201 - 4203 (2010/11/19)
A general method for the enantioselective hydrogenation of protected allylic amine derivatives is described. This procedure relies on the generation of a cationic ruthenium complex with the axially chiral ligand (-)-TMBTP. The utility is highlighted by th
