1254841-10-5Relevant academic research and scientific papers
Asymmetric hydrogenation of protected allylic amines
Steinhuebel, Dietrich P.,Krska, Shane W.,Alorati, Anthony,Baxter, Jenny M.,Belyk, Kevin,Bishop, Brian,Palucki, Michael,Sun, Yongkui,Davies, Ian W.
supporting information; experimental part, p. 4201 - 4203 (2010/11/19)
A general method for the enantioselective hydrogenation of protected allylic amine derivatives is described. This procedure relies on the generation of a cationic ruthenium complex with the axially chiral ligand (-)-TMBTP. The utility is highlighted by th
SYNTHESIS OF TELCAGEPANT AND INTERMEDIATES THEREOF
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Page/Page column 39-40, (2010/12/29)
Disclosed is an efficient synthesis for the manufacture of the caprolactam intermediate (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one: Formula and salts thereof, and an efficient preparation of telcagepant using the caprolact
