1254944-58-5

Basic information

• Product Name: C₁₇H₂₂N₆O₂
• Synonyms: C₁₇H₂₂N₆O₂
• CAS NO: 1254944-58-5
• Molecular Weight: 342.401
• Mol File: 1254944-58-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₂N₆O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₂N₆O₂(1254944-58-5)
• EPA Substance Registry System: C₁₇H₂₂N₆O₂(1254944-58-5)

Safety Data

• Hazardous Substances Data: 1254944-58-5(Hazardous Substances Data)

Upstream product

• 362661-29-8 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone 
• 100240-53-7 3-chloro-6-(4-phenylpiperazin-1-yl)pyridazine 
• 92-54-6 4-phenyl-1-piperazine 
• 1254944-53-0 C₁₉H₂₄N₄O₃ 

Relevant articles and documents

Synthesis and antimicrobial, acetylcholinesterase and butyrylcholinesterase inhibitory activities of novel ester and hydrazide derivatives of 3(2H)-pyridazinone

In the current study, some novel ethyl 6-[(substituted-phenylpiperazine]- 3(2H)-pyridazinone-2-yl propionate III and 6-[(substituted-phenylpiperazine]- 3(2H)-pyridazinone-2-yl propionohydrazide IV derivatives were synthesized as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The structures of these new pyridazinone derivatives were confirmed by their IR, 1H-NMR spectra and elementary analysis. 6-Substituted-3(2H)- pyridazinone-2-yl propionate IIIa-e derivatives showed significant inhibitory activity against AChE and BChE. 6-[4-(3-Trifluoromethylphenyl)-piperazine]-3(2H) -pyridazinone-2-yl propionate IIIe has been found to be the most active compound in terms of inhibition of either AChE or BChE. Compound IIIe exhibited inhibitory activity close to that of galantamine (CAS 357-70-0) and did not show any selectivity between the two enzymes. Also the antimicrobial activities of III and IV derivatives have been evaluated. All III and IV derivatives exhibited poor antibacterial activities but moderate antifungal activities. ECV ? Editio Cantor Verlag.