1254979-16-2

Basic information

• Product Name: 3-(cyclopropylmethyl)-7-(3-phenyl-1-pyrrolidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine
• CAS NO: 1254979-16-2
• Molecular Weight: 386.42
• Mol File: 1254979-16-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(cyclopropylmethyl)-7-(3-phenyl-1-pyrrolidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(cyclopropylmethyl)-7-(3-phenyl-1-pyrrolidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine(1254979-16-2)
• EPA Substance Registry System: 3-(cyclopropylmethyl)-7-(3-phenyl-1-pyrrolidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine(1254979-16-2)

Safety Data

• Hazardous Substances Data: 1254979-16-2(Hazardous Substances Data)

Upstream product

• 936-44-7 3-phenylpyrrolidine 
• 1254981-30-0 7-chloro-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine 
• 1254981-28-6 4-(benzyloxy)-2-hydrazineyl-3-(trifluoromethyl)pyridine 
• 1254981-27-5 4-(benzyloxy)-2-chloro-3-(trifluoromethyl)pyridine 
• 1186194-98-8 2,4-dichloro-3-(trifluoromethyl)pyridine 

Relevant articles and documents

Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8- trifluoromethyl[1,2,4]triazolo[4,3- a ]pyridine (JNJ-42153605): A positive allosteric modulator of the metabotropic glutamate 2 receptor

Advanced leads from a series of 1,2,4-triazolo[4,3-a]pyridines with mGlu2 receptor PAM activity are reported. By modification of the analogous imidazo[1,2-a]pyridine series, the newly reported leads have improved potency, in vitro ADMET, and hERG as well