125520-63-0

Usage

Type of compound

Derivative of oxadiazole

Biological activities

Antibacterial
Antifungal
Antiviral

Potential applications

Treatment of cancer
Treatment of various inflammatory conditions

Research significance

Subject of numerous studies due to diverse pharmacological effects

Therapeutic potential

Promising candidate for the development of new therapeutic agents

Upstream product

• 125520-60-7 3-phenyl-4-furoxancarboxamide 
• 125520-54-9 4-hydroxyimino-3-phenyl-5(4H)-isoxazolone 
• 125520-58-3 methyl 4-phenyl-3-furoxancarboxylate 
• 773837-37-9 sodium cyanide 
• 49558-03-4 4-nitro-3-phenylfuroxan 
• 157066-36-9 2-Oxy-4-phenyl-furazan-3-carbonyl chloride 
• 125520-55-0 3-carboxy-4-phenyl-1,2,5-oxadiazole 2-oxide 
• 184580-92-5 4-phenylfurazan-3-carbaldehyde oxime 5-oxide 
• 125520-62-9 4-phenyl-3-furoxancarbonitrile 

Downstream Products

• 857820-75-8 4-phenyl-furazan-3-carbonitrile 
• 125520-62-9 4-phenyl-3-furoxancarbonitrile 

Relevant academic research and scientific papers

Synthesis of cyanofuroxans from 4-nitrofuroxans via C–C bond forming reactions

A substitution reaction of 4-nitrofuroxans to prepare 4-cyanofuroxans is described. This substitution reaction was complicated by the reverse reaction and a judicious choice of cyanide source was important to enable this direct synthesis process. The optimized reaction conditions showed an excellent applicability for the synthesis of a range of 4-cyanofuroxans. 3-Cyanofuroxans, known to be thiol-mediated nitric oxide donors, could also be obtained by the thermal or photochemical isomerization of 4-cyanofuroxans. The developed cyanation of furoxans is a rare example of C–C bond-forming reaction on a furoxan ring.

Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents

The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and antischistosomal activity.

Characterisation of furoxancarbonitriles as a new class of vasodilators

The synthesis, structural characterization, NO-donor properties, and in vitro vasodilating activities of a series of furoxancarbonitriles 2, 17-22a, b are reported. Some derivatives (2b, 2a, 18b, 21b, 22b) are more potent vasodilating agents than sodium n

Phenylfuroxancarboxylic Acids and Their Derivatives

Synthesis and structure of the two isomeric furoxanecarboxylic acids 3 and 14 and a few of their derivatives 10-13, 15, 16 is reported. 1,3-dipolar cycloaddition reactions of the product obtained by thermal decomposition of 4-phenyl-3-furoxancarboxylic acid and thermal equilibration of furoxan derivatives are also discussed.