1255305-41-9Relevant academic research and scientific papers
Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952
Ikegashira, Kazutaka,Ikenogami, Taku,Yamasaki, Takayuki,Oka, Takahiro,Hase, Yasunori,Miyagawa, Naoki,Inagaki, Koji,Kawahara, Iichiro,Koga, Yoshihisa,Hashimoto, Hiromasa
supporting information, p. 873 - 877 (2019/02/13)
Optimization of novel azetidine compounds, which we had found as colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors, provided JTE-952 as a clinical candidate with high cellular activity (IC50 = 20 nM) and good pharmacokinetics pro
AZETIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF
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Page/Page column 23, (2011/01/05)
Compounds of formula [I]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salts or solvates thereof.
