125541-17-5

Usage

Uses

Used in Organic Synthesis:
4-(1-Piperdinyl)cyclohexanone ethylene ketal is used as a reagent in organic synthesis for the preparation of various organic compounds, leveraging its unique structure and reactivity.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(1-Piperdinyl)cyclohexanone ethylene ketal is used as a building block for the synthesis of medicinally active compounds, contributing to the development of new drugs.
Used in Research and Development:
4-(1-Piperdinyl)cyclohexanone ethylene ketal is also utilized in research and development settings to study its potential biological activities and pharmacological properties, exploring its therapeutic potential.

Upstream product

• 110-89-4 piperidine 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 110915-03-2 1-piperidino-4-methylenecyclohexane 
• 139025-95-9 C₁₆H₂₈N₂ 
• 60481-62-1 4-(1-piperidyl)-cyclohexanone 

Relevant academic research and scientific papers

Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures

Sodium triacetoxyborohydride is presented as a general reducing agent for the reductive amination of aldehydes and ketones. Procedures for using this mild and selective reagent have been developed for a wide variety of substrates. The scope of the reaction includes aliphatic acyclic and cyclic ketones, aliphatic and aromatic aldehydes, and primary and secondary amines including a variety of weakly basic and nonbasic amines. Limitations include reactions with aromatic and unsaturated ketones and some sterically hindered ketones and amines. 1,2-Dichloroethane (DCE) is the preferred reaction solvent, but reactions can also be carried out in tetrahydrofuran (THF) and occasionally in acetonitrile. Acetic acid may be used as catalyst with ketone reactions, but it is generally not needed with aldehydes. The procedure is carried out effectively in the presence of acid sensitive functional groups such as acetals and ketals; it can also be carried out in the presence of reducible functional groups such as C-C multiple bonds and cyano and nitro groups. Reactions are generally faster in DCE than in THF, and in both solvents, reactions are faster in the presence of AcOH. In comparison with other reductive amination procedures such as NaBH3CN/MeOH, borane-pyridine, and catalytic hydrogenation, NaBH(OAc)3 gave consistently higher yields and fewer side products. In the reductive amination of some aldehydes with primary amines where dialkylation is a problem we adopted a stepwise procedure involving imine formation in MeOH followed by reduction with NaBH4.

Reductive amination of aldehydes and ketones by using sodium triacetoxyborohydride

Sodium triacetoxyborohydride is a reagent of choice in the reductive amination of aldehydes and saturated aliphatic ketones with primary and secondary amines.

AN EFFICIENT SYNTHESIS OF 1-PHENYL-1-PIPERIDINO-trans-4-METHYLCYCLOHEXANE: UNANTICIPATED TOTAL STEREOSELECTIVITY IN THE CATALYTIC HYDROGENATION OF AN OLEFIN

A superior synthesis of the title compound, 1-phenyl-1-piperidino-trans-4-methylcyclohexane, is reported.The key step, the catalytic hydrogenation of 1-phenyl-1-piperidino-4-methylenecyclohexane hydrochloride, proceeds with unusual stereospecificity via a