125541-17-5

Basic information

• Product Name: 4-(1-PIPERDINYL)CYCLOHEXANONE ETHYLENE KETAL
• Synonyms: 4-(1-PIPERDINYL)CYCLOHEXANONE ETHYLENE KETAL
• CAS NO: 125541-17-5
• Molecular Formula: C₁₃H₂₃NO₂
• Molecular Weight: 225.32722
• Mol File: 125541-17-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(1-PIPERDINYL)CYCLOHEXANONE ETHYLENE KETAL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-PIPERDINYL)CYCLOHEXANONE ETHYLENE KETAL(125541-17-5)
• EPA Substance Registry System: 4-(1-PIPERDINYL)CYCLOHEXANONE ETHYLENE KETAL(125541-17-5)

Safety Data

• Hazardous Substances Data: 125541-17-5(Hazardous Substances Data)

Usage

General Description

4-(1-Piperdinyl)cyclohexanone ethylene ketal is a chemical compound that consists of a piperidine ring attached to a cyclohexanone ring, with an ethylene ketal group. It is commonly used in organic synthesis as a reagent for the preparation of various organic compounds. This chemical has potential applications in the pharmaceutical industry for the synthesis of medicinally active compounds. It can also be used as a building block for the preparation of complex organic molecules due to its versatile reactivity. Additionally, 4-(1-Piperdinyl)cyclohexanone ethylene ketal has been studied for its potential biological activities and pharmacological properties.

Upstream product

• 110-89-4 piperidine 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 60481-62-1 4-(1-piperidyl)-cyclohexanone 
• 139025-95-9 C₁₆H₂₈N₂ 
• 110915-03-2 1-piperidino-4-methylenecyclohexane 

Relevant articles and documents

Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures

Sodium triacetoxyborohydride is presented as a general reducing agent for the reductive amination of aldehydes and ketones. Procedures for using this mild and selective reagent have been developed for a wide variety of substrates. The scope of the reaction includes aliphatic acyclic and cyclic ketones, aliphatic and aromatic aldehydes, and primary and secondary amines including a variety of weakly basic and nonbasic amines. Limitations include reactions with aromatic and unsaturated ketones and some sterically hindered ketones and amines. 1,2-Dichloroethane (DCE) is the preferred reaction solvent, but reactions can also be carried out in tetrahydrofuran (THF) and occasionally in acetonitrile. Acetic acid may be used as catalyst with ketone reactions, but it is generally not needed with aldehydes. The procedure is carried out effectively in the presence of acid sensitive functional groups such as acetals and ketals; it can also be carried out in the presence of reducible functional groups such as C-C multiple bonds and cyano and nitro groups. Reactions are generally faster in DCE than in THF, and in both solvents, reactions are faster in the presence of AcOH. In comparison with other reductive amination procedures such as NaBH3CN/MeOH, borane-pyridine, and catalytic hydrogenation, NaBH(OAc)3 gave consistently higher yields and fewer side products. In the reductive amination of some aldehydes with primary amines where dialkylation is a problem we adopted a stepwise procedure involving imine formation in MeOH followed by reduction with NaBH4.

An Improved Method for Reductive Alkylation of Amines Using Titanium(IV) Isopropoxide and Sodium Cyanoborohydride

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