1255610-09-3

Basic information

• Product Name: Boc-gly-L-leu-L-lys(Z)-OMe
• CAS NO: 1255610-09-3
• Molecular Weight: 564.679
• Mol File: 1255610-09-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-gly-L-leu-L-lys(Z)-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-gly-L-leu-L-lys(Z)-OMe(1255610-09-3)
• EPA Substance Registry System: Boc-gly-L-leu-L-lys(Z)-OMe(1255610-09-3)

Safety Data

• Hazardous Substances Data: 1255610-09-3(Hazardous Substances Data)

Upstream product

• 37571-12-3 N-tert-butoxycarbonyl-L-leucyl-L-(N-ε-benzyloxycarbonyl)lysine methyl ester 
• 24498-31-5 (S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 4530-20-5 BOC-glycine 

Relevant articles and documents

Biodegradation of poly(2-hydroxyethyl methacrylate) (PHEMA) and poly{(2-hydroxyethyl methacrylate)-co-[poly(ethylene glycol) methyl ether methacrylate]} hydrogels containing peptide-based cross-linking agents

PHEMA-peptide and P[HEMA-co-(MeO-PEGMA)]-peptide conjugate hydrogels [where PHEMA ) poly(2- hydroxyethyl methacrylate; PEGMA ) poly(ethylene glycol) methacrylate] were readily prepared via photoinitiated free-radical polymerization in water. The PHEMA-peptide hydrogels were opaque and had a heterogeneous morphology of interconnected polymer droplets, characteristic of polymers that separate from the aqueous phase during the polymerization experiment. The P[HEMA-co-(MeO-PEGMA)]-peptide conjugates were transparent gels with a homogeneous morphology when formed in water, but when formed in aqueous NaCl solutions the P[HEMA-co-(MeO-PEGMA)]-peptide conjugates were also opaque and exhibited the heterogeneous morphology of interconnected polymer droplets. When incubated in solutions containing activated papain, P[HEMA-co-(MeOPEGMA)]- peptide conjugates underwent degradation that was characterized by macroscopic changes to sample shape and size, sample weight, and microscopic structure. PHEMA-peptide conjugates did not undergo any significant degradation when incubated with papain, although ninhydrin-staining experiments suggested that some peptide cross-linker groups were cleaved during the incubation. The difference in degradation behavior of PHEMA-peptide and P[HEMA-co-(MeO-PEGMA)]- peptide conjugates is attributed to differences in aqueous solubility of PHEMA and P[HEMA-co-(MeO-PEGMA)].