1255639-79-2Relevant academic research and scientific papers
Kinase inhibition by deoxy analogues of the resorcylic lactone L-783277
Liniger, Marc,Neuhaus, Christian,Hofmann, Tatjana,Fransioli-Ignazio, Luca,Jordi, Michel,Drueckes, Peter,Trappe, Joerg,Fabbro, Doriano,Altmann, Karl-Heinz
, p. 22 - 27 (2011/04/17)
The natural product L-783277 is a resorcylic lactone type covalent kinase inhibitor. We have prepared the 5′-deoxy analogue of L-783277 (1) in a stereoselective fashion. Remarkably, this analogue retains almost the full kinase inhibitory potential of natu
