1255701-22-4

Upstream product

• 41789-37-1 2,6-dichloro-5-pyridylmethyl chloride 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 50-00-0 formaldehyd 
• 1255701-23-5 (R)-2-((2,6-dichloropyridin-3-yl)methylamino)-1-phenylethanol 

Downstream Products

• 1375706-15-2 (R)-4-Methyl-N-(5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine 
• 1375706-18-5 (R)-4-Methyl-N-(5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine 
• 1375707-05-3 (R)-5-(2-Methoxy-6-(4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-ylamino)pyridin-3-yl)-1-methylpyridin-2(1H)-one 
• 1375707-17-7 (2R)-N-[6-Methoxy-5-(2-methyloxazol-5-yl)-2-pyridyl]-4-methyl-2-phenyl-3,5-dihydro-2H-pyrido[3,2-f][1,4]oxazepin-8-amine 
• 1375707-38-2 (2R)-N-[6-Methoxy-5-(1H-pyrazol-4-yl)-2-pyridyl]-4-methyl-2-phenyl-3,5-dihydro-2H-pyrido[3,2-f][1,4]oxazepin-8-amine 
• 1375711-77-5 tert-butyl 4-[2-methoxy-6-[[(2R)-4-methyl-2-phenyl-3,5-dihydro-2H-pyrido[3,2-f][1,4]oxazepin-8-yl]amino]-3-pyridyl]pyrazole-1-carboxylate 
• 1255700-83-4 (R)-N-(3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine 
• 1255700-98-1 (R)-(1-(4-(4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-ylamino)phenyl)-1H-imidazol-2-yl)methanol 
• 1255700-28-7 (R)-N-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine 
• 1255700-88-9 (R)-N-(6-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine 
• 1255700-96-9 (R)-4-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine 
• 1255700-86-7 (R)-4-methyl-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine 
• 1255700-97-0 (R)-4-methyl-N-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine 
• 1255701-21-3 (R)-8-chloro-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine 

Relevant academic research and scientific papers

Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases

The present invention relates to novel compounds of formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said compounds, processes for making said compounds, and their use as medicaments for treatment and/or prevention of Aβ-related diseases.

NEW COMPOUNDS MODULATING GAMMA-SECRETASE AND THEIR USE IN THE TREATMENT OF ALPHA BETA RELATED PATHOLOGIES, SUCH AS ALZHEIMER'S DISEASE

The present invention relates to novel compounds of formulae (I) and (II) and therapeutically acceptable salts thereof, their pharmaceutical compositions processes for making them and their use in therapeutic methods for treatment and/or prevention of var