1255705-75-9Relevant academic research and scientific papers
Synthesis of enantiopure fluorohydrins using alcohol dehydrogenases at high substrate concentrations
Borzeicka, Wioleta,Lavandera, Ivan,Gotor, Vicente
, p. 7312 - 7317 (2013/08/23)
The use of purified and overexpressed alcohol dehydrogenases to synthesize enantiopure fluorinated alcohols is shown. When the bioreductions were performed with ADH-A from Rhodococcus ruber overexpressed in E. coli, no external cofactor was necessary to obtain the enantiopure (R)-derivatives. Employing Lactobacillus brevis ADH, it was possible to achieve the synthesis of enantiopure (S)-fluorohydrins at a 0.5 M substrate concentration. Furthermore, due to the activated character of these substrates, a huge excess of the hydrogen donor was not necessary.
AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS
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Page/Page column 155, (2010/12/17)
Compounds of formula (I) as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein n, m, A, R1 and R2 have the significance given in claim 1. The compounds are useful as HSL inhibitors for the treatment of diabetes dyslipidemia, atherosclerosis and obesity.
