1255707-32-4

Basic information

• Product Name: Methyl 4-(benzyloxy)-3-(cyclopropylMethoxy)benzoate
• Synonyms: Methyl 4-(benzyloxy)-3-(cyclopropylMethoxy)benzoate
• CAS NO: 1255707-32-4
• Molecular Formula: C₁₉H₂₀O₄
• Molecular Weight: 312.3597
• Mol File: 1255707-32-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 4-(benzyloxy)-3-(cyclopropylMethoxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-(benzyloxy)-3-(cyclopropylMethoxy)benzoate(1255707-32-4)
• EPA Substance Registry System: Methyl 4-(benzyloxy)-3-(cyclopropylMethoxy)benzoate(1255707-32-4)

Safety Data

• Hazardous Substances Data: 1255707-32-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 1381886-14-1 4-(benzyloxy)-3-(cyclopropylmethoxy)benzaldehyde 
• 1255707-31-3 4-(benzyloxy)-3-(cyclopropylmethoxy)benzoic acid 
• 4049-39-2 4-benzyloxy-3-hydroxy-benzaldehyde 
• 2516-33-8 Cyclopropylmethanol 
• 87687-75-0 methyl 4-(benzyloxy)-3-hydroxybenzoate 

Downstream Products

• 1255707-31-3 4-(benzyloxy)-3-(cyclopropylmethoxy)benzoic acid 
• 848574-60-7 3-cyclopropylmethoxy-4-hydroxybenzoic acid methyl ester 

Relevant articles and documents

Intermediates for preparing roflumilast 3-cyclopropyl-methoxy-4-difluoro methoxybenzoic acid

The invention discloses a preparation method of roflumilast intermediate 3-cyclopropyl methoxyl-4-(difluoromethoxy)benzoic acid. A raw material of 3-hydroxy-4-benzyloxy benzaldehyde is subjected to 3-hydroxy cyclopropane methylation to convert aldehyde group to methyl carboxylate; then the material is subjected to catalytic hydrogenation to remove 4-benzyl group and subjected to difluoro methoxylation; and then the reaction product is hydrolyzed to obtain the 3-cyclopropyl methoxyl-4-(difluoromethoxy)benzoic acid. The method has the advantages of simple operation, mild reaction conditions and high regioselectivity, and is suitable for industrialized production.

1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS

Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.

BIS-(SULFONYLAMINO) DERIVATIVES FOR TREATMENT OF PAIN AND INFLAMMATION

The invention provides compounds of formula (I) wherein R1, R2, R3, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together