1255709-51-3

Upstream product

• 37553-65-4 N-tert-butoxycarbonyl-N-methyl-D-phenylalanine 
• 1610850-93-5 (R)-methyl 2-(2-(tert-butoxycarbonyl(methyl)amino)-N-methyl-3-phenylpropanamido)acetate 
• 1394985-57-9 (4S,5S,6S,7S)-5,7-dimethylnon-1-ene-4,6-diol 
• 1393482-69-3 (2R,3S,4S)-3-[(tert-butyl)dimethylsilyloxy]-2,4-dimethylhexanal 

Downstream Products

• 56-41-7 L-alanin 
• 3913-67-5 N-methylalanine 
• 1509-34-8 D-allo-isoleucine 
• 73-32-5 L-isoleucine 
• 488-15-3 (2R,3S)-2-hydroxy-3-methylpentanoic acid 
• 56564-52-4 N-methyl-D-phenylalanine 
• 194736-56-6 L-FDAA-L-N-methylalanine 
• 194736-83-9 D-N-Me-Phe-FDAA 

Relevant academic research and scientific papers

Matteson Homologation-Based Total Synthesis of Lagunamide A

Matteson homologation was found to be an excellent tool for the synthesis of the polyketide fragment of lagunamide A. Starting from a chiral boronic ester, a central building block containing all stereogenic centers of the polyketide chain was synthesized via six iterative Matteson homologation steps.

Diverse synthesis of marine cyclic depsipeptide lagunamide A and its analogues

The asymmetric total synthesis of lagunamide A (3.0%, 20 steps longest linear sequence) and its five analogues, including the structure dehydrated at the C37 position, are detailed in this report. The key feature in this diverse synthesis includes the ela