1255919-01-7

Basic information

• Product Name: 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one
• CAS NO: 1255919-01-7
• Molecular Weight: 522.628
• Mol File: 1255919-01-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one(1255919-01-7)
• EPA Substance Registry System: 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one(1255919-01-7)

Safety Data

• Hazardous Substances Data: 1255919-01-7(Hazardous Substances Data)

Usage

Uses

7-Despropyl 7-Phenyl Vardenafil is an impurity of Vardenafil (V098001), which is a selective phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction.

Upstream product

• 889943-46-8 2-ethoxybenzimidohydrazide 
• 2198-64-3 N-Benzoylalanine 
• 98-88-4 benzoyl chloride 
• 18637-00-8 2-ethoxy-benzamidine hydrochloride 
• 1393652-32-8 2-(2-ethoxyphenyl)-5-methyl-7-phenyl-imidazo[5,1-f][1,2,4]triazin-4(3H)-one 
• 1393652-31-7 C₁₇H₁₉NO₅ 
• 5308-25-8 4-ethylpiperazine 

Relevant articles and documents

Synthesis and spectral characterization of related substances of vardenafil, an erectile dysfunction drug

Vardenafil hydrochloride trihydrate (Levitra) is used to treat erectile dysfunction (ED) and is an inhibitor of phosphodiesterase type 5 (PDE-5) enzyme. It maintains higher levels of cyclic guanosine monophosphate (cGMP), relaxes smooth muscles, promotes penile blood flow, and enhances erectile function. During the bulk drug synthesis of vardenafil hydrochloride trihydrate, six related substances (impurities), vardenafil dimer, vardenafil N-oxide, vardenafil glycene, vardenafil oxopiperazine, vardenafil oxoacetic acid, and phenyl vardenafil were identified, and these are reported herein for the first time. The present work describes the synthesis and characterization of these impurities.