1255940-10-3Relevant academic research and scientific papers
Bicyclic substituted hydroxyphenylmethanones as novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases
Oster, Alexander,Hinsberger, Stefan,Werth, Ruth,Marchais-Oberwinkler, Sandrine,Frotscher, Martin,Hartmann, Rolf W.
supporting information; experimental part, p. 8176 - 8186 (2011/02/23)
Estradiol (E2), the most important estrogen in humans, is involved in the initiation and progression of estrogen-dependent diseases such as breast cancer and endometriosis. Its local production in the target cell is regulated by 17β-hydroxysteroid dehydro
