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1256033-62-1

3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-(2-fluorophenyl)-N-1H-pyrazol-3-ylimidazo[1,2-a]pyridin-2-amine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1256033-62-1 Structure

  • Basic information

    1. Product Name: 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-(2-fluorophenyl)-N-1H-pyrazol-3-ylimidazo[1,2-a]pyridin-2-amine
    2. Synonyms:
    3. CAS NO:1256033-62-1
    4. Molecular Formula:
    5. Molecular Weight: 401.406
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1256033-62-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-(2-fluorophenyl)-N-1H-pyrazol-3-ylimidazo[1,2-a]pyridin-2-amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-(2-fluorophenyl)-N-1H-pyrazol-3-ylimidazo[1,2-a]pyridin-2-amine(1256033-62-1)
    11. EPA Substance Registry System: 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-(2-fluorophenyl)-N-1H-pyrazol-3-ylimidazo[1,2-a]pyridin-2-amine(1256033-62-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1256033-62-1(Hazardous Substances Data)

1256033-62-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1256033-62-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,6,0,3 and 3 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1256033-62:
(9*1)+(8*2)+(7*5)+(6*6)+(5*0)+(4*3)+(3*3)+(2*6)+(1*2)=131
131 % 10 = 1
So 1256033-62-1 is a valid CAS Registry Number.

1256033-62-1Downstream Products

1256033-62-1Relevant articles and documents

Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors

Peterson, Emily A.,Boezio, Alessandro A.,Andrews, Paul S.,Boezio, Christiane M.,Bush, Tammy L.,Cheng, Alan C.,Choquette, Deborah,Coats, James R.,Colletti, Adria E.,Copeland, Katrina W.,Dupont, Michelle,Graceffa, Russell,Grubinska, Barbara,Kim, Joseph L.,Lewis, Richard T.,Liu, Jingzhou,Mullady, Erin L.,Potashman, Michele H.,Romero, Karina,Shaffer, Paul L.,Stanton, Mary K.,Stellwagen, John C.,Teffera, Yohannes,Yi, Shuyan,Cai, Ti,La, Daniel S.

scheme or table, p. 4967 - 4974 (2012/09/07)

mTOR is a critical regulator of cellular signaling downstream of multiple growth factors. The mTOR/PI3K/AKT pathway is frequently mutated in human cancers and is thus an important oncology target. Herein we report the evolution of our program to discover ATP-competitive mTOR inhibitors that demonstrate improved pharmacokinetic properties and selectivity compared to our previous leads. Through targeted SAR and structure-guided design, new imidazopyridine and imidazopyridazine scaffolds were identified that demonstrated superior inhibition of mTOR in cellular assays, selectivity over the closely related PIKK family and improved in vivo clearance over our previously reported benzimidazole series.

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