1256156-79-2Relevant academic research and scientific papers
Antiviral activities of 5-chlorobenzotriazole derivatives
Ibba, Roberta,Corona, Paola,Carta, Antonio,Giunchedi, Paolo,Loddo, Roberta,Sanna, Giuseppina,Delogu, Ilenia,Piras, Sandra
, p. 1247 - 1256 (2018/06/14)
Abstract: In this study, we designed and synthesized a series of new 5-chlorobenzotriazole derivatives. Compounds were tested for cytotoxicity and antiviral activity in cell-based assays against several positive single-stranded RNA viruses: BVDV, YFV, CVB-5, and Sb-1; two negative single-stranded RNA viruses: RSV and VSV; a double-stranded RNA virus (Reo-1); and two DNA viruses: VV and HSV-1. N-[4-(5-Chloro-2H-benzo[d][1,2,3]triazol-2-yl)phenyl]-3,4,5-trimethoxybenzamide turned out to be the most potent compound against?bovine viral diarrhea virus (BVDV). Its activity was shown to be comparable to the activity of the reference drug NM 107 (EC50 3.0 vs. 1.7?μM). It is going to be used as a lead compound for future antiviral drug developments. Graphical abstract: [Figure not available: see fulltext.].
A ligand-free copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes in PEG-water: An expeditious protocol towards regiospecific 1-aryl benzotriazoles
Mukhopadhyay, Chhanda,Tapaswi, Pradip Kumar,Butcher, Ray J.
supporting information; experimental part, p. 4720 - 4729 (2010/11/17)
An efficient and highly versatile method for the synthesis of diverse regiospecific 1-arylbenzotriazoles being important medicinal scaffolds, by the copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes of 2-haloaryldiazonium salts in PEG-water has been developed. A very simple reaction protocol, large number of substrate affordability and excellent yields are the main features of this methodology.
