1256157-16-0

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 159922-67-5 4-methoxyphenyl 3,4-O-isopropylidene-β-D-galactopyranoside 
• 3150-20-7 4-methoxyphenyl β-D-galactopyranoside 

Downstream Products

• 1256157-17-1 4-methoxyphenyl 2-O-benzyl-3,4-O-isopropylidene-α-L-fucopyranosyl-(1->2)-6-O-tert-butyldimethylsilyl-3,4-O-isopropylidene-β-D-galactopyranoside 
• 475987-13-4 p-methoxyphenyl 3,4,6-tri-O-benzoyl-β-D-galactopyranoside 

Relevant academic research and scientific papers

Synthesis of a new glycosphingolipid, neurosporaside, from Neurospora crassa

The glycosphingolipid neurosporaside (α-D-Glcp-(1→2)-β-D-Galp-(1→6)-β-D-Galp-(1→6)-β-D-Galp-(1→)-Cer) occurs in Neurospora crassa. We attempted to synthesize neurosporaside by block synthesis (route A) and linear synthesis (route B). Oligosaccharide derivatives were synthesized using trimethylsilyltrifluoromethanesulfonate and N-iodosuccinimide/trifluoromethane sulfonic acid as promoters. The target tetrasaccharide could not be attained via route A, but route B showed potential: glycosidic bonds (β-D-Galp-(1→6)-β-D-Galp-(1→6)-β-D-Galp) were formed stereoselectively, leading to the synthesis of glycosphingolipid 2.

Synthesis of the pentasaccharide repeating unit of Escherichia coli O128 antigen

A pentasaccharide, 4-methoxyphenyl 2-acetamido-2-deoxy-β-d- galactopyranosyl-(1→4)-α-d-galactopyranosyl-(1→3) -2-acetamido-2-deoxy-β-d-galactopyranosyl-(1→6)-[α-l- fucopyranosyl-(1→2)]-β-d-galactopyranoside (1), representing the repeating unit of Escherichia coli O128 antigen, was successfully prepared in 23% overall yield via a convergent '2+3' glycosylation strategy.