1256161-12-2Relevant academic research and scientific papers
Chelation-directed remote: Meta -C-H functionalization of aromatic aldehydes and ketones
Xie, Shuguang,Li, Sen,Ma, Wenqian,Xu, Xiaohua,Jin, Zhong
, p. 12408 - 12411 (2019)
We disclose herein the development of a versatile 1,2-diol directing template for palladium-catalyzed remote meta-C-H functionalization of aromatic aldehydes and ketones. In situ-generation of acetals and ketals, as well as removal afterwards, makes the C-H bond functionalization process more straightforward and efficient. This also represents the first example of chelation-directed meta-C-H functionalization of aromatic aldehydes and ketones.
Tandem nucleophilic addition-intramolecular aza-michael reaction: Facile synthesis of chiral fluorinated isoindolines
Fustero, Santos,Moscardo, Javier,Sanchez-Rosello, Maria,Rodriguez, Elsa,Barrio, Pablo
supporting information; experimental part, p. 5494 - 5497 (2011/02/23)
A highly stereoselective synthesis of fluorinated 1,3-disubstituted isoindolines is described. To this end, a tandem reaction consisting of a diastereoselective addition of fluorinated nucleophiles to Ellman's N-(tert-butanesulfinyl)imines followed by an
