Welcome to LookChem.com Sign In|Join Free

CAS

  • or
(2-bromo-pyridin-4-yl)-acetic acid ethyl ester is a chemical compound with the molecular formula C9H9BrNO2. It is an ester derivative of (2-bromo-pyridin-4-yl)-acetic acid, featuring a bromine substituent at the 2-position of the pyridine ring. (2-bromo-pyridin-4-yl)-acetic acid ethyl ester is commonly used as a building block in organic synthesis and medicinal chemistry, often serving as a precursor to various biologically active compounds. Its unique structure and reactivity make it a valuable tool for research in the field of organic chemistry.

1256337-24-2 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 1256337-24-2 Structure
  • Basic information

    1. Product Name: (2-bromo-pyridin-4-yl)-acetic acid ethyl ester
    2. Synonyms: (2-bromo-pyridin-4-yl)-acetic acid ethyl ester
    3. CAS NO:1256337-24-2
    4. Molecular Formula: C9H10BrNO2
    5. Molecular Weight: 244.0852
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1256337-24-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2-bromo-pyridin-4-yl)-acetic acid ethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2-bromo-pyridin-4-yl)-acetic acid ethyl ester(1256337-24-2)
    11. EPA Substance Registry System: (2-bromo-pyridin-4-yl)-acetic acid ethyl ester(1256337-24-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1256337-24-2(Hazardous Substances Data)

1256337-24-2 Usage

Uses

Used in Organic Synthesis:
(2-bromo-pyridin-4-yl)-acetic acid ethyl ester is used as a building block for the synthesis of various organic compounds. Its bromine substituent allows for further functionalization and modification, making it a versatile intermediate in the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (2-bromo-pyridin-4-yl)-acetic acid ethyl ester is used as a precursor to biologically active compounds. Its unique structure and reactivity enable the development of new pharmaceuticals with potential therapeutic applications.
Used in Pharmaceutical Development:
(2-bromo-pyridin-4-yl)-acetic acid ethyl ester may find applications in the development of pharmaceuticals, where its chemical properties can be harnessed to create new drugs with improved efficacy and selectivity.
Used in Agrochemical Development:
Additionally, (2-bromo-pyridin-4-yl)-acetic acid ethyl ester may also be utilized in the development of agrochemicals, contributing to the creation of new pesticides or herbicides with enhanced performance and selectivity.
Used in Organic Chemistry Research:
Due to its unique structure and reactivity, (2-bromo-pyridin-4-yl)-acetic acid ethyl ester is a valuable tool for research in the field of organic chemistry. It can be employed to study various chemical reactions and mechanisms, contributing to the advancement of knowledge in this scientific discipline.

Check Digit Verification of cas no

The CAS Registry Mumber 1256337-24-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,6,3,3 and 7 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1256337-24:
(9*1)+(8*2)+(7*5)+(6*6)+(5*3)+(4*3)+(3*7)+(2*2)+(1*4)=152
152 % 10 = 2
So 1256337-24-2 is a valid CAS Registry Number.

1256337-24-2Relevant articles and documents

SHMT INHIBITORS AND USES THEREOF

-

Paragraph 00241, (2018/06/30)

The present invention provides compounds, compositions thereof, and methods of using the same.

Potent Pan-Raf and Receptor Tyrosine Kinase Inhibitors Based on a Cyclopropyl Formamide Fragment Overcome Resistance

Zhang, Yanmin,Wang, Lu,Zhang, Qing,Zhu, Gaoyuan,Zhang, Zhimin,Zhou, Xiang,Chen, Yadong,Lu, Tao,Tang, Weifang

, p. 1439 - 1452 (2017/06/30)

While selective BRafV600E inhibitors have been proven effective clinically, acquired resistance rapidly develops through reactivation of the mitogen-activated protein kinase (MAPK) pathway. Simultaneous targeting of multiple nodes in the pathway offers the prospect of enhanced efficacy as well as reduced potential for acquired resistance. Replacement pyridine group of Y-1 by a cyclopropyl formamide group afforded I-01 as a novel multitargeted kinase inhibitor template. I-01 displayed enzyme potency against Pan-Raf and receptor tyrosine kinases (RTKs). Based on the binding mode of I-01, analogues I-02-I-18 were designed and synthesized. The most promising compound I-16 potently inhibits all subtypes of Rafs with IC50 values of 3.49 (BRafV600E), 8.86 (ARaf), 5.78 (BRafWT), and 1.65 nM (CRaf), respectively. I-16 not only exhibit comparable antiproliferative activities with positive control compounds against HepG2, SW579, MV4-11, and COLO205 cell lines, but also suppress the proliferation of melanoma SK-MEL-2 harboring overexpressed BRafWT with IC50 values of 0.93 μM. The Western blot results for the ERK inhibition in human melanoma SK-MEL-2 cell lines show that I-16 inhibits the proliferation of SK-MEL-2 cell lines without paradoxical activation of ERK, which support the hypothesis that the inhibition of Pan-Raf and RTKs might be a tractable strategy to overcome the resistance of melanoma induced by the therapy with the current selective BRafV600E inhibitors.

Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders

-

Page/Page column 33, (2012/07/28)

The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

BETA-LACTAMASE INHIBITORS

-

Page/Page column 122-123, (2010/12/17)

Disclosed herein are α-aminoboronic acids and their derivatives which act as inhibitors of beta-lactamases. Also disclosed herein are pharmaceutical compositions comprising α-aminoboronic acids and methods of use thereof.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1256337-24-2