125653-55-6

Basic information

• Product Name: (MOD)2P(O)H
• Synonyms: BIS(3,5-DIMETHYL-4-METHOXYPHENYL)PHOSPHINE OXIDE;(MOD)2P(O)H
• CAS NO: 125653-55-6
• Molecular Formula: C₁₈H₂₃O₃P
• Molecular Weight: 318.35
• Mol File: 125653-55-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (MOD)2P(O)H(CAS DataBase Reference)
• NIST Chemistry Reference: (MOD)2P(O)H(125653-55-6)
• EPA Substance Registry System: (MOD)2P(O)H(125653-55-6)

Safety Data

• Hazardous Substances Data: 125653-55-6(Hazardous Substances Data)

Usage

General Description

(MOD)2P(O)H is a chemical compound with the molecular formula C2H8O2P. It is a dialkylphosphinic acid that is commonly used as a ligand in coordination chemistry and as a precursor for various organophosphorus compounds. (MOD)2P(O)H has two alkyl groups attached to a phosphorus atom, and a hydroxy group bonded to the phosphorus atom. It is a colorless liquid with a slightly fruity odor, and it is relatively stable under normal conditions. (MOD)2P(O)H is used in a variety of applications, including in the production of pesticides, flame retardants, and plasticizers, as well as in organic synthesis and as a reagent in industrial processes.

Upstream product

• 14804-38-7 5-bromo-2-methoxy-1,3-dimethylbenzene 
• 762-04-9 phosphonic acid diethyl ester 
• 762-04-9 Diethyl phosphonate 
• 185416-17-5 3,5-dimethyl-4-methoxyphenylmagnesium bromide 

Downstream Products

• 1312366-27-0 C₂₀H₂₇O₃P 
• 136802-85-2 bis(3,5-dimethyl-4-methoxy-phenyl)chlorophosphine 
• 1262588-16-8 (R)-3-(bis(4-methoxy-3,5-dimethylphenyl)phosphoryl)-1,3-diphenylpropan-1-one 
• 122708-97-8 bis(4-methoxy-3,5-dimethylphenyl)-phosphine 

Relevant articles and documents

Development of effective bidentate diphosphine ligands of ruthenium catalysts toward practical hydrogenation of carboxylic acids

Hydrogenation of carboxylic acids (CAs) to alcohols represents one of the most ideal reduction methods for utilizing abundant CAs as alternative carbon and energy sources. However, systematic studies on the effects of metal-to-ligand relationships on the catalytic activity of metal complex catalysts are scarce. We previously demonstrated a rational methodology for CA hydrogenation, in which CA-derived cationic metal carboxylate [(PP)M(OCOR)]+ (M = Ru and Re; P = one P coordination) served as the catalyst prototype for CA self-induced CA hydrogenation. Herein, we report systematic trial- and-error studies on how we could achieve higher catalytic activity by modifying the structure of bidentate diphosphine (PP) ligands of molecular Ru catalysts. Carbon chains connecting two P atoms as well as Ar groups substituted on the P atoms of PP ligands were intensively varied, and the induction of active Ru catalysts from precatalyst Ru(acac)3 was surveyed extensively. As a result, the activity and durability of the (PP)Ru catalyst substantially increased compared to those of other molecular Ru catalyst systems, including our original Ru catalysts. The results validate our approach for improving the catalyst performance, which would benefit further advancement of CA self-induced CA hydrogenation.

Ruthenium-catalyzed regio- and enantioselective allylic substitution with water: Direct synthesis of chiral allylic alcohols

Less is more: A new route to access chiral allylic alcohols through the regio- and enantioselective substitution of monosubstituted allylic chlorides with water has been developed. The reaction is catalyzed effectively by planar-chiral cyclopentadienyl ruthenium complexes (see scheme). Copyright

PROCESS FOR PREPARATION OF DIPHOSPHINE COMPOUNDS AND INTERMEDIATES FOR THE PROCESS

A production method of a_compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.