1256601-45-2Relevant academic research and scientific papers
Synthesis and properties of chiral thioureas bearing an additional function at a remote position tethered by a 1,5- disubstituted triazole
Takasu, Kiyosei,Azuma, Takumi,Enkhtaivan, Iderbat,Takemoto, Yoshiji
, p. 8327 - 8348 (2011/03/18)
The synthesis and properties of multifunctional thioureas bearing a variety of functional groups at a position remote from the thiourea moiety are described. A 1, 5- disubstituted triazole tether connected with a thiourea and another functional group was synthesized via ruthenium catalyzed Huisgen cycloaddition. We demonstrate the utility of the synthetic thioureas as asymmetric catalysts and probes for the mechanistic elucidation of the course of the Michael reaction of an α,β-unsaturated imide.
