1256827-34-5Relevant articles and documents
Concise syntheses of trifluoromethylated cyclic and acyclic analogues of cADPR
Huang, Xiangchen,Dong, Min,Liu, Jian,Zhang, Kehui,Yang, Zhenjun,Zhang, Liangren,Zhang, Lihe
experimental part, p. 8689 - 8701 (2011/02/28)
A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9- disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation. A series of acyclic analogues of cADPR were also designed and synthesized. These compounds could be useful molecules for studying the structure-activity relationship of cADPR analogues and exploring the cADPR/RyR Ca2+ signalling system