1256846-42-0

Basic information

• Product Name: 2-(1-phenylethyl)benzo[d][1,2]selenazol-3(2H)-one
• Synonyms: 2-(1-phenylethyl)benzo[d][1,2]selenazol-3(2H)-one
• CAS NO: 1256846-42-0
• Molecular Weight: 302.234
• Mol File: 1256846-42-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(1-phenylethyl)benzo[d][1,2]selenazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-phenylethyl)benzo[d][1,2]selenazol-3(2H)-one(1256846-42-0)
• EPA Substance Registry System: 2-(1-phenylethyl)benzo[d][1,2]selenazol-3(2H)-one(1256846-42-0)

Safety Data

• Hazardous Substances Data: 1256846-42-0(Hazardous Substances Data)

Upstream product

• 3480-59-9 N-(1-phenylethyl)benzamide 
• 98-88-4 benzoyl chloride 
• 618-36-0 rac-methylbenzylamine 
• 7782-49-2 selenium 
• 299954-52-2 (±)-N-(o-chlorobenzoyl)-α-methylbenzylamine 

Downstream Products

• 1256846-58-8 C₂₁H₁₉NOSe 
• 175612-96-1 C₃₀H₂₈N₂O₂Se₂ 
• 1256846-59-9 C₂₃H₂₃NOSe 

Relevant articles and documents

Highly efficient synthesis and antioxidant capacity of N-substituted benzisoselenazol-3(2H)-ones

A new, general one step synthesis of N-substituted benzisoselenazol-3(2H)-ones based on the reaction of o-iodobenzamides with lithium diselenide, is described. A series of alkyl and aryl derivatives was obtained in high yields (up to 98%). Their GPx-like antioxidant activity, tested by NMR, showed a significantly higher activity than ebselen.

Isoselenazolones as catalysts for the activation of bromine: Bromolactonization of alkenoic acids and oxidation of alcohols

Isoselenazolones were synthesized by a copper-catalyzed Se-N bond forming reaction between 2-halobenzamides and selenium powder. The catalytic activity of the various isoselenazolones was studied in the bromolactonization of pent-4-enoic acid. Isoselenazolone 9 was studied as a catalyst in several reactions: the bromolactonization of a series of alkenoic acids with bromine or N-bromosuccinimide (NBS) in the presence of potassium carbonate as base, the bromoesterification of a series of alkenes using NBS and a variety of carboxylic acids, and the oxidation of secondary alcohols to ketones using bromine as an oxidizing reagent. Mechanistic details of the isoselenazolone-catalyzed bromination reaction were revealed by 77Se NMR spectroscopic and ES-MS studies. The oxidative addition of bromine to the isoselenazolone gives the isoselenazolone(IV) dibromide, which could be responsible for the activation of bromine under the reaction conditions. Steric effects from an N-phenylethyl group on the amide of the isoselenazolone and electron-withdrawing fluoro substituents on the benzo fused-ring of the isoselenazolone appear to enhance the stability of the isoselenazolone as a catalyst for the bromination reaction.