1256937-01-5Relevant articles and documents
Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis
B?urle, Stefan,Nagel, Jens,Peters, Olaf,Br?uer, Nico,Ter Laak, Antonius,Preusse, Cornelia,Rottmann, Antje,Heldmann, Dieter,Bothe, Ulrich,Blume, Thorsten,Zorn, Ludwig,Walter, Daryl,Zollner, Thomas M.,Steinmeyer, Andreas,Langer, Gernot
, p. 2541 - 2563 (2019)
The presence and growth of endometrial tissue outside the uterine cavity in endometriosis patients are primarily driven by hormone-dependent and inflammatory processes - the latter being frequently associated with severe, acute, and chronic pelvic pain. T
EP4 antagonist dihydrobenzo imidazolecarboxylic deriv. new
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Paragraph 0159; 0187, (2016/10/08)
The present invention relates to novel benzimidazole derivatives of the general formula (I), processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected w
Discovery of 2-aminoimidazopyridine adenosine A2A receptor antagonists
McGuinness, Brian F.,Cole, Andrew G.,Dong, Guizhen,Brescia, Marc-Raleigh,Shao, Yuefei,Henderson, Ian,Rokosz, Laura L.,Stauffer, Tara M.,Mannava, Neelima,Kimble, Earl F.,Hicks, Catherine,White, Nicole,Wines, Pamela G.,Quadros, Elizabeth
scheme or table, p. 6845 - 6849 (2011/01/04)
A novel series of adenosine A2A receptor antagonists was identified by high-throughput screening of an encoded combinatorial compound collection. The initial hits were optimized for A2A binding affinity, A1 selectivity, an
