1256961-43-9Relevant articles and documents
Anti-mycobacterial, cytotoxic activities of Knoevenagel and (E)-α,β-unsaturated esters and ketones from 2-chloronicotinaldehydes
Suman, Pathi,Rao, Rayala Nageswara,Raju, Bhimapaka China,Sriram, Dharmarajan,Koushik, Pulla Venkat
, p. 199 - 206 (2014/03/21)
Series of 2-chloronicotinaldehyde Knoevenagel derivatives 3a-r; (E)-α,β-unsaturated esters and ketones 5a-k were prepared and evaluated for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv (Mtb). Compounds 3e,
New and facile approach for the synthesis of (E)-α,β-unsaturated esters and ketones
China Raju, Bhimapaka,Suman, Pathi
supporting information; experimental part, p. 11840 - 11842 (2011/01/12)
A general and practical synthesis of (E)-α,β-unsaturated esters and ketones was achieved by the reaction of carbonyl compounds with ethyl-4,4,4-trifluoroacetoacetate and trifluoro-substituted 1,3-diketones in the presence of piperidine in dichloromethane at raoom temperature (≈40°C) with excellent stereoselectivity (see scheme).