1257-19-8

Basic information

• Product Name: 1,4-Bis(2,3,4-triMethoxybenzyl)piperazine
• Synonyms: 1,4-Bis(2,3,4-triMethoxybenzyl)piperazine;1,4-Bis[(2,3,4-triMethoxyphenyl)Methyl]piperazine;HexaMetazidine;TriMetazidine EP IMpurity-B;Trimetazidine Impurity B
• CAS NO: 1257-19-8
• Molecular Formula: C₂₄H₃₄N₂O₆
• Molecular Weight: 446.53656
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1257-19-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 108-109℃
• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• CAS DataBase Reference: 1,4-Bis(2,3,4-triMethoxybenzyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Bis(2,3,4-triMethoxybenzyl)piperazine(1257-19-8)
• EPA Substance Registry System: 1,4-Bis(2,3,4-triMethoxybenzyl)piperazine(1257-19-8)

Safety Data

• Hazardous Substances Data: 1257-19-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1257-19-8 differently. You can refer to the following data:
1. Hexametazidine is an impurity of Trimetazidine (T795610). Trimetazidine impurity B. Hexametazidine can protect the myocardium from injury by ischemia and reperfusion.
2. Hexametazidine is an impurity of Trimetazidine (T795610). Trimetazidine impurity B. Hexametazidine can protect the myocardium from injury by ischemia and reperfusion.

Upstream product

• 110-85-0 piperazine 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 

Relevant articles and documents

Curved-US he oxazine derivatives and its preparation method

The invention belongs to the field of pharmaceutical chemistry and discloses a trimetazidine derivative I, namely N,N-[(2,3,4-trimethoxyphenyl)dimethyl]piperazine, and a preparation method thereof. The invention also provides structure confirmation and synthesis methods of impurities of trimetazidine hydrochloride medicines and preparations thereof, and the use of the prepared impurity reference substance to quality control of trimetazidine hydrochloride and preparations thereof.