1257051-37-8

Basic information

• Product Name: N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide
• Synonyms: N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide
• CAS NO: 1257051-37-8
• Molecular Weight: 835.787
• Mol File: 1257051-37-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide(1257051-37-8)
• EPA Substance Registry System: N-[2-((5R,6R)-5-(tert-butyldimethylsilyloxy)-6-(3-(2,2-dimethoxyethyl)-2-iodo-6-methoxyphenoxy)cyclohex-1-enyl)]-N-methyl-2,4-dinitrobenzenesulfonamide(1257051-37-8)

Safety Data

• Hazardous Substances Data: 1257051-37-8(Hazardous Substances Data)

Upstream product

• 73057-71-3 1-(3-hydroxypropyl)-1-cyclopentanol 
• 1257051-35-6 N-[2-((R)-5-(tert-butyldimethylsilyloxy)-6-oxocyclohex-1-enyl)ethyl]-N-methyl-2,4-dinitrobenzenesulfonamide 
• 1257051-34-5 N-[2-(5-acetoxy-6-oxocyclohex-1-enyl)ethyl]-N-methyl-2,4-dinitrobenzenesulfonamide 
• 1257051-33-4 N-methyl-N-[2-(6-oxocyclohex-1-enyl)ethyl]-2,4-dinitrobenzenesulfonamide 
• 1257051-32-3 N-(3-cyclopentenylpropyl)-N-methyl-2,4-dinitrobenzenesulfonamide 
• 1257051-31-2 3-cyclopentenylpropyl methanesulfonate 
• 916225-97-3 2-iodo-6-methoxy-3-(2,2-dimethoxyethyl)phenol 
• 1257051-36-7 N-[2-((5R,6S)-5-(tert-butyldimethylsilyloxy)-6-hydroxycyclohex-1-enyl)ethyl]-N-methyl-2,4-dinitrobenzenesulfonamide 

Downstream Products

• 1201905-45-4 C₃₂H₄₅N₃O₁₁SSi 
• 1201905-46-5 N-[2-[(5aR,6R,9aS)-6,7-dihydro-6-hydroxy-1-(2,2-dimethoxyethyl)-4-methoxy-9a(5aH)-dibenzofuranyl]ethyl]-N-methyl-2,4-dinitrobenzenesulfonamide 
• 1201905-48-7 N-[2-[(5aR,9aS)-6,7-dihydro-1-(2,2-dimethoxyethyl)-4-methoxy-6-oxo-9a(5aH)-dibenzofuranyl]ethyl]-N-methyl-2,4-dinitrobenzenesulfonamide 
• 1201905-49-8 C₂₄H₂₃N₃O₁₀S 
• 1201905-50-1 C₂₄H₂₁N₃O₉S 
• 509-66-0 (4R,7aR,12bS)-9-methoxy-3-methyl-2,3,4,6-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one 
• 57-27-2 MORPHIN 
• 467-13-0 codeinone 

Relevant articles and documents

Total synthesis of (-)-morphine

We have developed an efficient total synthesis of (-)-morphine in 5% overall yield with the longest linear sequence consisting of 17 steps from 2-cyclohexen-1-one. The cyclohexenol unit was prepared by means of an enzymatic resolution and a Suzuki-Miyaura coupling as key steps. Construction of the morphinan core features an intramolecular aldol reaction and an intramolecular 1,6-addition. Furthermore, mild deprotection conditions to remove the 2,4-dinitrobenzenesulfonyl (DNs) group enabled the facile construction of the morphinan skeleton. We have also established an efficient synthetic route to a cyclohexenol unit containing an N-methyl-DNsamide moiety.